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KMID : 0603519970020020131
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Journal of Korean Association of Cancer Prevention
1997 Volume.2 No. 2 p.131 ~ p.141
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Effect of α-Linolenic Acid Rich in Perilla Oil on Colonic Mucosal Cell Proliferation, Fatty Acid Pattern of Phosphatidyl Inositol and 1,2-diacylglycerol Content in Colon Carcinogenesis of Rats
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Kim Chae-Jong
Park Hyun-Suh
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Abstract
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The objective of this study was to observe the effect of a-linolenic acid rich in perilla oil on colonic mucosal co]1 proliferation and fatty acid compositon of phosphatidyl inositol (PI) and the levels of 1,2-diacylglycerol (DAG), TXB2 and PGEB which were known as biomarkers for colon cancer, Eighty male Sprague Dawley rats, at 7 weeks old, were divided into two groups (saline for control and DMH treatment) and each group was again subdivided into two groups of fat (corn oil or perilla oil). Each rat was intramusculary injected with saline or 1,2-dimethylhydrazine (DMH) for 6 weeks(total dose of 180 mg/kg body weight) and simultaneously fed the experimental diet for 20 weeks containing dietary fat (corn oil or perilla oil) at 15% by weight. DMH treatment, regardless of the type of dietary fat, significantly increased cell proliferation by enlarging proliferative zone, labeling index and crypt length and increased colonic mucosal levels of DAG and PI arachidonic acid distribution. Compared to corn oil, perilla oil significantly reduced cell proliferation by decreasing labeling index, proliferative zone and crypt length in colonic mucosa and also reduced colonic mucosal levels of DAG, TXB2, PGE2 and PI arachidonic acid distribution. Therefore, n-3 α-linolenic acid rich in perilla oil could be very important source in reducing the risk factor for colon cancer and it is suggested to use more perilla oil for meal preparation.
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KEYWORD
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Colon cancer biomarker, Cell proliferation, Diacylglycerol, Phosphatidyl inositol, TXB2, PGE2, Corn oil, Perilla oil
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